Students will explain the mechanisms of genetic inheritance and describe the environmental and genetic causes of gene mutation and alteration of gene expression. Students will model how phenotypes are determined through genotypes through a protein synthesis simulation. Students will research the genetic basis for sickle cell anemia and present to a group on how a single nucleotide change can lead to disease. Students will read an article on beneficial mutations and discuss the potential consequences for mimicking genetic mutations in humans. Students will compare and contrast eukaryotic organisms and prokaryotic organisms method of transcription and translation.
Lectures and Notes:
Formal Lab Write-up
Video Worksheet: Cosmos episode 2 “Some of the Things That Molecules Do”
DNA, RNA, and Protein Synthesis Part 1
DNA, RNA, and Protein Synthesis Part 2
DNA, RNA, and Protein Synthesis Part 3
Labs and Classroom Activities:
Lab: UV Light and Skin Cancer (rubric)
Protein Synthesis Virtual Lab (Glencoe) (online link)
HHMI: Lactose Intolerance-Fact or Fiction?
HHMI: Regulation of the Lactase Gene (Click and Learn Activity)
Lab: A Study of Lactose Intolerance (rubric)
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Introduction to Protein Synthesis
From DNA to protein – 3D
Transcription and Translation
mRNA Translation (Basic)
Genetic Engineering Will Change Everything Forever – CRISPR
CRISPR: A Gene-Editing Superpower
Epigenetics: Why Inheritance Is Weirder Than We Thought
TedEd What is epigenetics?
Protein Synthesis and the Lean, Mean Ribosome Machines