Students will build on their foundation of genetics by investigating current techniques used in genomic research and genetic engineering. Concepts such as PCR, DNA fingerprinting, transformation, and cloning and their use in therapeutic and forensic science will be examined. To further explore this continually growing branch of science learners will participate in online/interactive simulations as well perform gel electrophoresis and bacterial transformation. Gel electrophoresis will be used to model the use of biotechnology in forensics. Students will run samples of DNA to observe genomic differences in amounts of introns, illustrating how individuals have unique DNA fingerprints. Transgenics, the incorporation of foreign DNA, will be used to explore the potential of these tools by transforming bacteria to express pGLO, a bioluminescence gene from jellyfish. These laboratory activities will be use Student mastery of genetic technology will culminate in a debate addressing the ethics behind the exploration and use of genetic manipulation in therapeutic/ecological roles.
Lectures and Notes:
Labs and Classroom Activities:
TedEd: How Mendel’s pea plants helped us understand genetics
TedEd: Where do genes come from?
TedEd: What happens when your DNA is damaged?
Genetic Engineering Will Change Everything Forever – CRISPR
CRISPR: A Gene-Editing Superpower
Epigenetics: Why Inheritance Is Weirder Than We Thought
TedEd What is epigenetics?
Bozeman Science: Mendelian Genetics
Learn.Genetics: Insights From Identical Twins